Richard Lehman's Medical Blog is a gem.He's writing for other doctors (primarily other British doctors working in Britain's National Health Service). For average idiot's, like me, he is always a challenge to follow with any real understanding but if you have a continuing interest in medicine but no formal education - read every one of Richard's Blogs - they appear about every two weeks (fortnightly in British) and for me they are must reads.
A quick feel for his writing:"So I was strongly inclined to pass over this Danish study, but I’m glad that I didn’t. It is quite an intellectual tour de force as well as a logistic feat, combining three types of study within the population of Copenhagen, and it shows how the deft use of genomics can obviate the need for a randomised controlled trial.
The key element here is mendelian randomisation, the reshuffling of genetic material which happens each time we make a baby. I won’t go into further detail here, but if you are interested in such cutting edge stuff, I would strongly recommend a look at this paper and its accompanying editorial (p.2386)."
Of course he can sound a little condescending but I'm sure he is not:Cardiac computerised tomography exposes patients to large amounts of radiation for large sums of money and often negligible clinical benefit. In the USA, you can apparently get it done in “small community hospitals”, which were lumped together with larger centres in this exceedingly unsophisticated before-and-after study.
Before these centres participated in the Advanced Cardiovascular Imaging Consortium in Michigan, they used twice the dose of X-rays that they did afterwards. But if you really need to know how furred-up your coronary arteries are, and want much smaller doses of radiation, it’s best to wait for the arrival of prospectively triggered sequential scanning in your area, or even better, single heartbeat acquisitions.
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