Tuesday, January 8, 2008

Prescription Sleep Aids

The Mayo Clinic Health Letter for January 2008 has a good summary of prescription drugs to aid sleep. Mayo makes the distinction between finding it difficult to get off to sleep as contrasted with the problem of staying asleep (sleep-maintenance insomnia). Older adults more commonly have sleep-maintenance insomnia.

The Health Letter has a useful summary of drugs used for helping getting off to sleep and for those that help one stay asleep.

The newest class of sleep drug are the melatonin agonists. These are related to the natural hormone melatonin. Rozerem is the brand name and it seems somewhat weak in its affect but not habit forming.

Another group of sleep aids currently being heavily promoted are from the class called non-benzodiazepine hypnotics. This includes brands such as Ambien, Ambien CR, Lunesta and Sonata. It appears that older adults can take these fairly well with little residual drowsiness. However Mayo say that there are some reports of amnesia after taking them. That said this new class of non-benzodiazepine hypnotics is much better than their predecessors, the benzodiazepine which have been used for the last 40 years.

Sonata (one of the non-benzodiazepine hypnotics) is short acting and wears off quickly.

Mayo is fairly dismissive about non-prescription medication sleep aids such as Benadryl, Somine and Unisom saying they have minimal effectiveness.

The Mayo summary is:
  • Ambien - Useful for initiating sleep, sleep onset 7 to 27 minutes, low risk for dependency
  • Ambien CR - Useful for initiating sleep, sleep onset 30 minutes, more chance of morning drowsiness than with Ambien
  • Lunesta - Good for both initiating sleep and sleep maintence, sleep onset 10 minutes, low risk dependency.
  • Sonata - Good for night awakening and for sleep initiation, sleep onset 30 minutes, short acting so you can take it middle of night and be OK in morning.
Remember that these are all on prescription, so listen to your doctor, take exactly as prescribed and read all the warnings.

Difficulty sleeping can reach an extreme in sleep apnea. This topic is worthy of a blog all on its own.

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2 Comments:

Blogger sleepaidsreviews said...

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October 29, 2011 at 12:18 AM  
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June 2, 2012 at 11:48 AM  

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